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V D J Recombination

Vdj Recombination
Author: Pierre Ferrier
Publisher: Springer Science & Business Media
ISBN: 1441902961
Size: 54.86 MB
Format: PDF, ePub
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v(D)J recombination: for the community of immunologists and developmental biologists, the molecular route by which B and T lymphocytes acquire their unique function of affording adaptive immunity. Yet, for many-from experienced scientists to trainees-it represents a (rather too) sophisticated process whose true insight is excessively demanding. However, when not simplyconsidered as a private ground for a few aficionados, it can be seen as a way of understanding how maturelympho cytes carry on their basic functions. For the group of aficionados-which includes this editor-it is an elegant paradigm featuring many fascinating evolutionary achievements of which the biological world alone has the secret. These include a subtle biochemical principle most likelyhijacked some 470 million years ago from an ancestral gene invader and since then cleverly adapted by jawed vertebrates to precisely cleave and rearrange their antigen receptor (Ig andTCR)loci. This invader would itself have assigned the services of the nonhomologous end joining (NHEJ) DNArepair machinery as well as various DNApolymerases or transferases to work in concert with developmental clues in lymphoid cell lineages to generate an immune repertoire and efficient host surveillance while avoiding autoimmunity. Recently, important new refinements in these systems have emerged, continuing to challenge ourknowledge andbeliefs. These arejust thetopics covered by the senior authors-all established leaders in this field-and their colleagues, whilst writing the various chapters in V(D)J Recombination.
Fundamental Immunology
Language: en
Pages: 1603
Authors: William E. Paul
Categories: Medical
Type: BOOK - Published: 2008 - Publisher: Lippincott Williams & Wilkins
Now thoroughly revised and updated, this comprehensive, up-to-date text is ideal for graduate students, post-doctoral fellows, microbiologists, infectious disease physicians, and any physician who treats diseases in which immunologic mechanisms play a role.
Language: en
Pages: 56
Authors: Leonard I. Zon
Categories: Medical
Type: BOOK - Published: 2001-04-12 - Publisher: Oxford University Press
Hematopoiesis, or the process of blood formation, has been extensively studied at both basic and clinical levels. Human diseases such as thalassemia, immunodeficiency, and leukemia represent defects in this process. Approaches to treat these disorders have required a basic understanding of the biology of blood cells. For instance, hemapoietic stem
Transgenesis and Targeted Mutagenesis in Immunology
Language: en
Pages: 316
Authors: Leonard I. Zon
Categories: Medical
Type: BOOK - Published: 2014-06-28 - Publisher: Elsevier
Investigations into the field of immunology are rapidly expanding with the use of genetically altered mice at the embryonic stage. This breakthrough laboratory guide provides a complete study of transgenesis and targeted mutagenesis in laboratory mice that will be valued by researchers looking for fresh observations and interpretations when designing
Language: en
Pages: 552
Authors: David K. Male
Categories: Medical
Type: BOOK - Published: 2006 - Publisher: Elsevier Health Sciences
Extensively updated, this edition offers readers a carefully structured approach to learning the building blocks of the immune system, cells, organs and major receptor molecules, as well as initiation and actions of the immune response, especially in a clinical context.
Molecular Biology of B Cells
Language: en
Pages: 600
Authors: Tasuku Honjo, Michael Reth, Andreas Radbruch, Frederick Alt
Categories: Science
Type: BOOK - Published: 2014-10-09 - Publisher: Elsevier
Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of
Stryer Biochemie
Language: de
Pages: 1401
Authors: Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto jr., Lubert Stryer
Categories: Science
Type: BOOK - Published: 2017-12-05 - Publisher: Springer-Verlag
„Oft kopiert, nie erreicht.“ Biologen heute Seit vier Jahrzehnten prägt dieses außergewöhnliche Lehrbuch weltweit die Lehre der Biochemie. Die überaus klare und präzise Art der Darstellung, die Aktualität, die ausgefeilte Didaktik und die Verständlichkeit sind zu Markenzeichen dieses von Lehrenden wie Lernenden hoch geschätzten Standardwerkes geworden. Sie zeichnen auch die
The Scid Mouse
Language: en
Pages: 263
Authors: Melvin J. Bosma, Robert A. Phillips, Walter Schuler
Categories: Medical
Type: BOOK - Published: 2013-03-07 - Publisher: Springer Science & Business Media
During routine genetic screening of several immunoglobulin heavy chain congenic mouse strains in 1980, one of us (MB) was surprised to find that several mice in the C.B-17IIcr strain, which was being maintained in a specific-pathogen-free facility of the Fox Chase Cancer Center (Philadelphia, PA), did not express serum immunoglobulin
Language: en
Pages: 342
Authors: Timothy Illidge, P. W. M. Johnson
Categories: Medical
Type: BOOK - Published: 2005 - Publisher: Springer Science & Business Media
Covers numerous lymphomas, including Mantle Cell, Follicular, Burkitt's, Marginal Zone, Peripheral T Cell and Hodgkins.
Biochemistry and Molecular Biology Compendium
Language: en
Pages: 412
Authors: Roger L. Lundblad
Categories: Medical
Type: BOOK - Published: 2020-04-24 - Publisher: CRC Press
This book is an accessible resource offering practical information not found in more database-oriented resources. The first chapter lists acronyms with definitions, and a glossary of terms and subjects used in biochemistry, molecular biology, biotechnology, proteomics, genomics, and systems biology. There follows chapters on chemicals employed in biochemistry and molecular
DNA Damage, DNA Repair and Disease Volume 1
Language: en
Pages: 428
Authors: R. Stephen Lloyd, Miral Dizdaroglu
Categories: Science
Type: BOOK - Published: 2020-11-19 - Publisher: Royal Society of Chemistry
The overall aim of this book is to give scientists in academia and industry a comprehensive overview of the field of DNA damage and DNA repair and related human diseases.