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Validation Of Alternative Methods For Toxicity Testing

Validation Of Alternative Methods For Toxicity Testing
Author: Chantra Eskes
Publisher: Springer
ISBN: 3319338269
Size: 57.48 MB
Format: PDF, ePub
View: 476
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This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology. Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are given on the state-of-the-art and on approaches that have resulted in successfully validated and accepted alternative methods. The second section focuses on the evolution of validation principles and practice that are necessary to ensure fit-for-purpose validation that has the greatest impact on international regulatory acceptance of alternative methods. In this context validation needs to keep pace with the considerable scientific advancements being made in toxicology, the availability of sophisticated tools and techniques that can be applied in a variety of ways, and the increasing societal and regulatory demands for better safety assessment. This book will be a useful resource for scientists in the field of toxicology, both from industry and academia, developing new test methods, strategies or techniques, as well as Governmental and regulatory authorities interested in understanding the principles and practicalities of validation of alternative methods for toxicity testing.
Validation of Alternative Methods for Toxicity Testing
Language: en
Pages: 407
Authors: Chantra Eskes, Maurice Whelan
Categories: Medical
Type: BOOK - Published: 2016-09-26 - Publisher: Springer
This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem
Validation of Alternative Methods. Toxicity Testing Without Animals
Language: en
Pages:
Authors: Chantra Eskes, Maurice Whelan
Categories: Medical
Type: BOOK - Published: 2003 - Publisher:
Books about Validation of Alternative Methods. Toxicity Testing Without Animals
Alternatives for Dermal Toxicity Testing
Language: en
Pages: 592
Authors: Chantra Eskes, Erwin van Vliet, Howard I. Maibach
Categories: Medical
Type: BOOK - Published: 2017-11-21 - Publisher: Springer
This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is
Toxicity Testing for Assessment of Environmental Agents
Language: en
Pages: 270
Authors: National Research Council, Division on Earth and Life Studies, Institute for Laboratory Animal Research, Board on Environmental Studies and Toxicology, Committee on Toxicity Testing and Assessment of Environmental Agents
Categories: Nature
Type: BOOK - Published: 2006-05-07 - Publisher: National Academies Press
Toxicity testing in laboratory animals provides much of the information used by the Environmental Protection Agency (EPA) to assess the hazards and risks associated with exposure to environmental agents that might harm public health or the environment. The data are used to establish maximum acceptable concentrations of environmental agents in
The History of Alternative Test Methods in Toxicology
Language: en
Pages: 352
Authors: National Research Council, Division on Earth and Life Studies, Institute for Laboratory Animal Research, Board on Environmental Studies and Toxicology, Committee on Toxicity Testing and Assessment of Environmental Agents
Categories: Medical
Type: BOOK - Published: 2018-10-20 - Publisher: Academic Press
The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history
Environmental Health Perspectives
Language: en
Pages:
Authors: National Research Council, Division on Earth and Life Studies, Institute for Laboratory Animal Research, Board on Environmental Studies and Toxicology, Committee on Toxicity Testing and Assessment of Environmental Agents
Categories: Environmental health
Type: BOOK - Published: 2010 - Publisher:
Books about Environmental Health Perspectives
Principles of Toxicology Testing, Second Edition
Language: en
Pages: 362
Authors: Frank A Barile
Categories: Medical
Type: BOOK - Published: 2013-04-02 - Publisher: CRC Press
Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism,
In Vitro Methods in Aquatic Ecotoxicology
Language: en
Pages: 472
Authors: Carmel Mothersill, Brian Austin
Categories: Nature
Type: BOOK - Published: 2003-08-14 - Publisher: Springer Science & Business Media
For the first time, here is a book that focuses on in vitro approaches to the study of the toxicology of polluting agents (including heavy metals, radionuclides, micro-organics, estrogenic compounds, and complex mixtures) in the aquatic environment. The importance of in vitro methods is that they allow standardised techniques to
Information Resources in Toxicology
Language: en
Pages: 1552
Authors: P.J. Bert Hakkinen, Asish Mohapatra, Steven G. G. Gilbert
Categories: Science
Type: BOOK - Published: 2009-08-19 - Publisher: Academic Press
This latest version of Information Resources in Toxicology (IRT) continues a tradition established in 1982 with the publication of the first edition in presenting an extensive itemization, review, and commentary on the information infrastructure of the field. This book is a unique wide-ranging, international, annotated bibliography and compendium of major
Handbuch Validierung in der Analytik
Language: de
Pages: 525
Authors: Stavros Kromidas
Categories: Science
Type: BOOK - Published: 2012-03-14 - Publisher: John Wiley & Sons
Validierung als Eignungsnachweis für die Qualität der Analytik wird heute von jedem Auftraggeber und Kunden erwartet. Damit stehen Laborleitung und Qualtitätsmanagement vor den Fragen wie: - Was muß unbedingt validiert werden und welche Aussagekraft haben Validierungsdaten? - Was wird von wem vorgegeben und wo sind wir frei? - Wie können