Cancer Stem Cells


Cancer Stem Cells
Author: Rüdiger Martin Zimmerer
Publisher: Sudwestdeutscher Verlag Fur Hochschulschriften AG
ISBN: 9783838113678
Size: 45.35 MB
Format: PDF, ePub, Docs
View: 4337
Get Books

Cancer Stem Cell Features In Established Melanoma Cell Lines

Cancer Stem Cells by Rüdiger Martin Zimmerer, Cancer Stem Cell Features In Established Melanoma Cell Lines Books available in PDF, EPUB, Mobi Format. Download Cancer Stem Cell Features In Established Melanoma Cell Lines books, Cancer is increasingly being viewed as a stem cell disease. According to the cancer stem cell hypothesis, tumour initiation and growth are driven by a minor subset of stem-cell-like cancer cells. These cancer stem cells (CSC) self-renew to give rise to additional CSC and differentiate to generate phenotypically diverse progeny with limited proliferative potential. CSC are capable of reconstituting tumours upon transplantation relative to bulk tumour cells or non-tumourigenic cancer cells. This model, first developed in human myeloid leukaemia, has been extended to solid tumours, such as breast and brain cancer. Most cancer stem cells were first isolated based on the expression of surface markers to distinguish CSC from cancer cells with more limited proliferative potential. CSC are usually rare in clinical specimens and hardly amenable to functional studies or to analysis of gene expression profiles. In this study a panel of melanoma cell lines was screened to identify cellular reagents sharing typical CSC features including expression of specific surface markers and genes, capacity to grow in spheroids and high clonogenic capacity.


Cancer Stem Cell Features in Established Melanoma Cell Lines
Language: en
Pages: 120
Authors: Rüdiger Martin Zimmerer
Categories:
Type: BOOK - Published: 2010-03 - Publisher: Sudwestdeutscher Verlag Fur Hochschulschriften AG
Cancer is increasingly being viewed as a stem cell disease. According to the cancer stem cell hypothesis, tumour initiation and growth are driven by a minor subset of stem-cell-like cancer cells. These cancer stem cells (CSC) self-renew to give rise to additional CSC and differentiate to generate phenotypically diverse progeny
Stem Cells and Cancer Stem Cells, Volume 13
Language: en
Pages: 123
Authors: M.A. Hayat
Categories: Medical
Type: BOOK - Published: 2016-08-23 - Publisher: Springer
This is the thirteenth volume in a series which presents current understanding of stem cells and cancer stem cells. This book presents many relevant topics including the different sources of cancer stem cells: the features, roles and clinical potential of stem cells emerge from engaging with this comprehensive work. Chapters
The Role of MicroRNAs in Regulating Cancer Stem Cells
Language: en
Pages:
Authors: Musaffe Tuna, Christopher I. Amos
Categories: Medical
Type: BOOK - Published: 2011 - Publisher:
Books about The Role of MicroRNAs in Regulating Cancer Stem Cells
Cancer Stem Cells
Language: en
Pages: 264
Authors: Lucie Laplane
Categories: Science
Type: BOOK - Published: 2016-06-06 - Publisher: Harvard University Press
A new therapeutic strategy could break the stalemate in the war on cancer by targeting not all cancerous cells but the small fraction that lie at the root of cancers. Lucie Laplane offers a comprehensive analysis of cancer stem cell theory, based on an original interdisciplinary approach that combines biology,
Cancer Stem Cells
Language: en
Pages: 542
Authors: Huiping Liu, Justin Durla Lathia
Categories: Science
Type: BOOK - Published: 2016-08-16 - Publisher: Elsevier
Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance introduces the basic concepts and advanced understanding of cancer stem cells, covering general overviews, organ-specific identifications, and their characteristic mechanisms. The book also explores innovative therapeutic strategies in preclinical and clinical trials to target
Cancer Stem Cells
Language: en
Pages: 552
Authors: Vinagolu K. Rajasekhar
Categories: Science
Type: BOOK - Published: 2014-01-27 - Publisher: John Wiley & Sons
Cancer Stem Cells covers a wide range of topics incancer stem cell biology, including the functional characteristicsof cancer stem cells and how they're generated, where they arelocalized, the means by which cancer stem cells can be targeted,and how cancer stem cells can be reprogrammed back to normal tissuestem cells. Each
Cancer Stem Cells in Solid Tumors
Language: en
Pages: 478
Authors: Alison L. Allan
Categories: Science
Type: BOOK - Published: 2011-08-12 - Publisher: Springer Science & Business Media
The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical
Cancer Stem Cells
Language: en
Pages: 263
Authors: Otmar D. Wiestler, Bernhard Haendler, D. Mumberg
Categories: Medical
Type: BOOK - Published: 2007-08-03 - Publisher: Springer Science & Business Media
Cancer stem cells have originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor as they divide much more slowly and have very efficient drug resistance mechanisms. Current treatments might largely spare cancer stem cells. This book
Cancer Metastasis and Cancer Stem Cell/Niche
Language: en
Pages: 157
Authors: Takanori Kawaguchi
Categories: Medical
Type: BOOK - Published: 2016-11-04 - Publisher: Bentham Science Publishers
A malignant tumor is an actively growing tissue, composed of cells derived from a single cell line that has undergone irreversible differentiation. These cells are invasive and also metastasize in the body, resulting in malignant cancer. Recent research suggests that a malignant tumor originates from cancer stem cells (CSC) accompanied
The Cancer Stem Cell Niche
Language: en
Pages: 246
Authors: Susie Nilsson
Categories: Science
Type: BOOK - Published: 2021-02-01 - Publisher: Academic Press
The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone